PENGARUH PUASA INTERMITEN TERHADAP NILAI TRIGLISERIDA PASIEN OBESITAS DI SURABAYA

Renata Primasari; Deorina Roully Gratia Siregar

doi:10.62354/jurnalmedicare.v5i3.565

Authors

Renata Primasari Universitas 17 Agustus 1945 Surabaya
Deorina Roully Gratia Siregar Fakultas Kedokteran, Universitas 17 Agustus 1945 Surabaya

DOI:

https://doi.org/10.62354/jurnalmedicare.v5i3.565

Abstract

Background: Obesity is frequently accompanied by hypertriglyceridemia, which increases cardiometabolic risk. Objective: To evaluate the effect of a 12-hour intermittent fasting regimen, performed on three non-consecutive days per week for six weeks, on triglyceride levels in patients with obesity. Methods: This quasi-experimental study employed a non-equivalent control group pretest–posttest design involving 50 participants, divided into an intervention group (n=25) and a control group (n=25). The intervention group fasted from 06:00 to 18:00, while the control group maintained their usual dietary habits. Fasting triglyceride levels were measured before and after the intervention. Data were analyzed using paired tests, Welch’s t-test, and ANCOVA. Results: Triglyceride levels decreased from 251.64 to 178.80 mg/dL in the intervention group and to 227.20 mg/dL in the control group. The adjusted reduction was significantly greater in the intervention group by 48.40 mg/dL (95% CI: 33.60–63.20; p<0.001), with a compliance rate of 90.2%. Conclusion: A 12-hour intermittent fasting regimen performed three times weekly for six weeks reduced triglyceride levels more effectively than a usual diet. Larger randomized controlled trials are needed to confirm these findings. Intermittent fasting may represent a simple, low-cost intervention with potential application in primary healthcare, accompanied by continuous monitoring of dietary intake and physical activity.

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Keywords:

puasa intermiten, obesitas, trigliserida, dislipidemia, surabaya

References

1. World Health Organization. Obesity and overweight. Geneva: World Health Organization; 2025. Available from: https://www.who.int/news-room/fact-sheets/detail/obesity-and-overweight

2. Badan Kebijakan Pembangunan Kesehatan. Survei Kesehatan Indonesia 2023 dalam Angka. Jakarta: Kementerian Kesehatan Republik Indonesia; 2024.

3. Kementerian Kesehatan Republik Indonesia. Keputusan Menteri Kesehatan Republik Indonesia Nomor HK.01.07/MENKES/509/2025 tentang Pedoman Nasional Pelayanan Kedokteran Tata Laksana Obesitas Dewasa. Jakarta: Kementerian Kesehatan Republik Indonesia; 2025.

4. Virani SS, Morris PB, Agarwala A, Ballantyne CM, Birtcher KK, Kris-Etherton PM, et al. 2021 ACC Expert Consensus Decision Pathway on the management of ASCVD risk reduction in patients with persistent hypertriglyceridemia. J Am Coll Cardiol. 2021;78(9):960-993. doi:10.1016/j.jacc.2021.06.011.

5. de Cabo R, Mattson MP. Effects of intermittent fasting on health, aging, and disease. N Engl J Med. 2019;381(26):2541-2551. doi:10.1056/NEJMra1905136.

6. Anton SD, Moehl K, Donahoo WT, Marosi K, Lee SA, Mainous AG 3rd, et al. Flipping the metabolic switch: understanding and applying the health benefits of fasting. Obesity. 2018;26(2):254-268. doi:10.1002/oby.22065.

7. Patikorn C, Roubal K, Veettil SK, Chandran V, Pham T, Lee YY, et al. Intermittent fasting and obesity-related health outcomes: an umbrella review of meta-analyses of randomized clinical trials. JAMA Netw Open. 2021;4(12):e2139558. doi:10.1001/jamanetworkopen.2021.39558.

8. Meng H, Zhu L, Kord-Varkaneh H, Santos HO, Tinsley GM, Fu P. Effects of intermittent fasting and energy-restricted diets on lipid profile: a systematic review and meta-analysis. Nutrition. 2020;77:110801. doi:10.1016/j.nut.2020.110801.

9. Semnani-Azad Z, Khan TA, Chiavaroli L, Chen V, Bhatt HA, Chen A, et al. Intermittent fasting strategies and their effects on body weight and other cardiometabolic risk factors: systematic review and network meta-analysis of randomised clinical trials. BMJ. 2025;389:e082007. doi:10.1136/bmj-2024-082007.

10. Maroofi M, Nasrollahzadeh J. Effect of intermittent versus continuous calorie restriction on body weight and cardiometabolic risk markers in subjects with overweight or obesity and mild-to-moderate hypertriglyceridemia: a randomized trial. Lipids Health Dis. 2020;19:216. doi:10.1186/s12944-020-01399-0.

11. Gabel K, Hoddy KK, Haggerty N, Song J, Kroeger CM, Trepanowski JF, et al. Effects of 8-hour time restricted feeding on body weight and metabolic disease risk factors in obese adults: a pilot study. Nutr Healthy Aging. 2018;4(4):345-353. doi:10.3233/NHA-170036.

12. Wilkinson MJ, Manoogian ENC, Zadourian A, Lo H, Fakhouri S, Shoghi A, et al. Ten-hour time-restricted eating reduces weight, blood pressure, and atherogenic lipids in patients with metabolic syndrome. Cell Metab. 2020;31(1):92-104.e5. doi:10.1016/j.cmet.2019.11.004.

13. Lowe DA, Wu N, Rohdin-Bibby L, Moore AH, Kelly N, Liu YE, et al. Effects of time-restricted eating on weight loss and other metabolic parameters in women and men with overweight and obesity: the TREAT randomized clinical trial. JAMA Intern Med. 2020;180(11):1491-1499. doi:10.1001/jamainternmed.2020.4153.

14. Liu L, Chen W, Wu D, Hu F. Metabolic efficacy of time-restricted eating in adults: a systematic review and meta-analysis of randomized controlled trials. J Clin Endocrinol Metab. 2022;107(12):3428-3441. doi:10.1210/clinem/dgac570.

15. Wei X, Lin B, Huang Y, Yang S, Huang C, Shi L, et al. Effects of time-restricted eating on nonalcoholic fatty liver disease: the TREATY-FLD randomized clinical trial. JAMA Netw Open. 2023;6(3):e233513. doi:10.1001/jamanetworkopen.2023.3513.

16. Jamshed H, Steger FL, Bryan DR, Richman JS, Warriner AH, Hanick CJ, et al. Effectiveness of early time-restricted eating for weight loss, fat loss, and cardiometabolic health in adults with obesity: a randomized clinical trial. JAMA Intern Med. 2022;182(9):953-962. doi:10.1001/jamainternmed.2022.3050.

17. Catenacci VA, Ostendorf DM, Pan Z, Bing K, Wayland LT, Hess JM, et al. The effect of 4:3 intermittent fasting on weight loss at 12 months: a randomized clinical trial. Ann Intern Med. 2025;178(5):634-644. doi:10.7326/ANNALS-24-01631.